Comment on "Regularizing capacity of metabolic networks"
Molecular Networks
2008-02-06 v2
Abstract
In a recent paper, Marr, Muller-Linow and Hutt [Phys. Rev. E 75, 041917 (2007)] investigate an artificial dynamic system on metabolic networks. They find a less complex time evolution of this dynamic system in real networks, compared to networks of reference models. The authors argue that this suggests that metabolic network structure is a major factor behind the stability of biochemical steady states. We reanalyze the same kind of data using a dynamic system modeling actual reaction kinetics. The conclusions about stability, from our analysis, are inconsistent with those of Marr et al. We argue that this issue calls for a more detailed type of modeling.
Cite
@article{arxiv.0705.4084,
title = {Comment on "Regularizing capacity of metabolic networks"},
author = {Petter Holme and Mikael Huss},
journal= {arXiv preprint arXiv:0705.4084},
year = {2008}
}