Co-evolution is Incompatible with the Markov Assumption in Phylogenetics
Populations and Evolution
2010-08-05 v2 Artificial Intelligence
Computational Engineering, Finance, and Science
Abstract
Markov models are extensively used in the analysis of molecular evolution. A recent line of research suggests that pairs of proteins with functional and physical interactions co-evolve with each other. Here, by analyzing hundreds of orthologous sets of three fungi and their co-evolutionary relations, we demonstrate that co-evolutionary assumption may violate the Markov assumption. Our results encourage developing alternative probabilistic models for the cases of extreme co-evolution.
Cite
@article{arxiv.1008.0322,
title = {Co-evolution is Incompatible with the Markov Assumption in Phylogenetics},
author = {Tamir Tuller and Elchanan Mossel},
journal= {arXiv preprint arXiv:1008.0322},
year = {2010}
}