Cis-Regulatory Modules Drive Dynamic Patterns of a Multicellular System
Quantitative Methods
2009-03-24 v1 Molecular Networks
Abstract
How intracellular and extracellular signals are integrated by transcription factors is essential for understanding complex cellular patterns at the population level. In this Letter, by using a synthetic genetic oscillator coupled to a quorum-sensing apparatus, we propose an experimentally feasible cis-regulatory module (CRM) which performs four possible logic operations (ANDN, ORN, NOR and NAND) of input signals. We show both numerically and theoretically that these different CRMs drive fundamentally different dynamic patterns, such as synchronization, clustering and splay state.
Cite
@article{arxiv.0903.3719,
title = {Cis-Regulatory Modules Drive Dynamic Patterns of a Multicellular System},
author = {Jiajun Zhang and Zhanjiang Yuan and Tianshou Zhou},
journal= {arXiv preprint arXiv:0903.3719},
year = {2009}
}
Comments
4 pages, 3 figures