Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers
Abstract
Cell migration in morphogenesis and cancer metastasis typically involves interplay between different cell types. We construct and study a minimal, one-dimensional model comprised of two different motile cells with each cell represented as an active elastic dimer. The interaction between the two cells via cadherins is modeled as a spring that can rupture beyond a threshold force as it undergoes dynamic loading via the attached motile cells. We obtain a phase diagram consisting of chase-and-run dynamics and clumping dynamics as a function of the stiffness of the interaction spring and the threshold force. We also find that while feedback between cadherins and cell-substrate interaction via integrins accentuates the chase-run behavior, feedback is not necessary for it.
Keywords
Cite
@article{arxiv.1612.09052,
title = {Chase-and-run dynamics in cell motility and the molecular rupture of interacting active elastic dimers},
author = {David Mayett and Nicholas Bitten and Moumita Das and J. M. Schwarz},
journal= {arXiv preprint arXiv:1612.09052},
year = {2017}
}