ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins
Abstract
Gene expression is a noisy process and several mechanisms, both transcriptional and posttranscriptional, can stabilize protein levels in cells. Much work has focused on the role of miRNAs, showing in particular that miRNA-mediated regulation can buffer expression noise for lowly expressed genes. Here, using in silico simulations and mathematical modeling, we demonstrate that miRNAs can exert a much broader influence on protein levels by orchestrating competition-induced crosstalk between mRNAs. Most notably, we find that miRNA-mediated cross-talk (i) can stabilize protein levels across the full range of gene expression rates, and (ii) modifies the correlation pattern of co-regulated interacting proteins, changing the sign of correlations from negative to positive. The latter feature may constitute a potentially robust signature of the existence of RNA crosstalk induced by endogenous competition for miRNAs in standard cellular conditions.
Cite
@article{arxiv.1703.02758,
title = {ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins},
author = {Araks Martirosyan and Andrea De Martino and Andrea Pagnani and Enzo Marinari},
journal= {arXiv preprint arXiv:1703.02758},
year = {2017}
}