The problem of variable cell survival probability along the spread-out Bragg peak is one of the long standing problems in planning and optimisation of ion-beam therapy. This problem is considered using the multiscale approach to the physics of ion-beam therapy. The physical reasons for this problem are analysed and understood on a quantitative level. A recipe of solution to this problem is suggested using this approach. This recipe can be used in the design of a novel treatment planning and optimisation based on fundamental science.
@article{arxiv.1703.00596,
title = {Cell survival probability in a spread-out Bragg peak for novel treatment planning},
author = {Eugene Surdutovich and Andrey V. Solov'yov},
journal= {arXiv preprint arXiv:1703.00596},
year = {2017}
}