We report narrow linewidth optomechanical oscillation of a silica microsphere immersed in a buffer solution. Through a novel optomechanical transduction sensing approach, single 10-nm-radius silica beads and Bovine serum albumin (BSA) protein molecules with a molecular weight of 66 kDalton were detected. This approach predicts the detection of 3.9 kDalton single molecules at a signal-to-noise ration above unity.
@article{arxiv.1504.03727,
title = {Cavity optomechanical transduction sensing of single molecules},
author = {Wenyan Yu and Wei C. Jiang and Qiang Lin and and Tao Lu},
journal= {arXiv preprint arXiv:1504.03727},
year = {2016}
}