Cable dynamics applied to long-length scale mechanics of DNA
Abstract
This paper introduces the use of cable dynamics models as a means to explore the mechanics of DNA on long-length scales. It is on these length scales that DNA forms twisted and curved three-dimensional shapes known as supercoils and loops. These long-length scale DNA structures have a pronounced influence on the functions of this molecule within the cell including the packing of DNA in the cell nucleus, transcription, replication and gene repair. We provide a short background to the mechanics of DNA and suggest the logical connection to the mechanics of a low tension cable. A computational model is then summarized and example results are presented for DNA supercoiling and looping.
Cite
@article{arxiv.physics/0702197,
title = {Cable dynamics applied to long-length scale mechanics of DNA},
author = {Sachin Goyal and Todd Lillian and Noel C. Perkins and Edgar Meyhofer},
journal= {arXiv preprint arXiv:physics/0702197},
year = {2007}
}
Comments
14 pages, 7 figures, An invited keynote speech, in CD-ROM Proceedings of Sixth International Symposium on Cable Dynamics, Charleston, SC, 19-22 Sept, 2005