Buffering variability in cell regulation motifs close to criticality
Adaptation and Self-Organizing Systems
2025-08-04 v1 Quantitative Methods
Abstract
Bistable biological regulatory systems need to cope with stochastic noise to fine-tune their function close to bifurcation points. Here, we study stability properties of this regime in generic systems to demonstrate that cooperative interactions buffer system variability, hampering noise-induced regime shifts. Our analysis also shows that, in the considered cooperativity range, impending regime shifts can be generically detected by statistical early warning signals from distributional data. Our generic framework, based on minimal models, can be used to extract robustness and variability properties of more complex models and empirical data close to criticality.
Keywords
Cite
@article{arxiv.2212.08600,
title = {Buffering variability in cell regulation motifs close to criticality},
author = {Daniele Proverbio and Arthur N. Montanari and Alexander Skupin and Jorge Gonçalves},
journal= {arXiv preprint arXiv:2212.08600},
year = {2025}
}