Beyond Target Scores: Measuring Off-Target Drift in Diffusion-Based Medical Image Editing

Diffusion models can now edit medical images in visually plausible ways, but the standard evaluation question is too narrow: did the target score increase? In clinical imaging, target findings are entangled with co-morbidities, acquisition effects, and selection bias, so a model can appear successful by changing correlated non-target findings rather than isolating the intended pathology. We introduce CIB-Med-1, a trajectory-level benchmark for controlled biomarker editing in chest radiography. CIB-Med-1 evaluates directional pleural effusion editing through calibrated target progression, inversion rate, and off-target semantic drift over 14 clinically motivated nuisance axes. The benchmark exposes a reward-hacking failure mode in which diffusion editors increase effusion scores while simultaneously altering parenchymal, cardiomediastinal, pleural, chronic, or artifact-related findings. We further present a constrained diffusion guidance baseline that optimizes target progression subject to bounded off-target change. Across held-out radiographs, the constrained editor preserves target progression ($\rho_{\mathrm{trend}}=0.88$ vs. $0.90$ for unconstrained guidance) while reducing median off-target drift from $0.46$ to $0.20$ and 90th-percentile drift from $0.98$ to $0.33$. Drift magnitude tracks empirical target--off-target association, supporting the view that semantic instability is structured rather than incidental. A blinded human validation probe with radiology trainees further shows stronger agreement with intended progression orderings ($\tau=0.61$ vs.\ $0.29$ for Pix2Pix). These results argue that medical image editing should be evaluated as trajectory-level semantic control, not as endpoint score maximization.