Asymptotic Analysis of the Narrow Escape Problem in Dendritic Spine Shaped Domain: Three Dimension

This paper deals with the three-dimensional narrow escape problem in dendritic spine shaped domain, which is composed of a relatively big head and a thin neck. The narrow escape problem is to compute the mean first passage time of Brownian particles traveling from inside the head to the end of the neck. The original model is to solve a mixed Dirichlet-Neumann boundary value problem for the Poisson equation in the composite domain, and is computationally challenging. In this paper we seek to transfer the original problem to a mixed Robin-Neumann boundary value problem by dropping the thin neck part, and rigorously derive the asymptotic expansion of the mean first passage time with high order terms. This study is a nontrivial generalization of the work in \cite{Li}, where a two-dimensional analogue domain is considered.