Asymptotic absorption-time distributions in extinction-prone Markov processes

We characterize absorption-time distributions for birth-death Markov chains with an absorbing boundary. For "extinction-prone" chains (which drift on average toward the absorbing state) the asymptotic distribution is Gaussian, Gumbel, or belongs to a family of skewed distributions. The latter two cases arise when the dynamics slow down dramatically near the boundary. Several models of evolution, epidemics, and chemical reactions fall into these classes; in each case we establish new results for the absorption-time distribution. Applications to African sleeping sickness are discussed.