Analytic models for mechanotransduction: gating a mechanosensitive channel
Biomolecules
2009-11-10 v1
Abstract
Analytic estimates for the forces and free energy generated by bilayer deformation reveal a compelling and intuitive model for MscL channel gating analogous to the nucleation of a second phase. We argue that the competition between hydrophobic mismatch and tension results in a surprisingly rich story which can provide both a quantitative comparison to measurements of opening tension for MscL when reconstituted in bilayers of different thickness and qualitative insights into the function of the MscL channel and other transmembrane proteins.
Keywords
Cite
@article{arxiv.q-bio/0311010,
title = {Analytic models for mechanotransduction: gating a mechanosensitive channel},
author = {Paul Wiggins and Rob Phillips},
journal= {arXiv preprint arXiv:q-bio/0311010},
year = {2009}
}