Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts
Computational Engineering, Finance, and Science
2013-10-01 v1 Computational Geometry
Discrete Mathematics
Cell Behavior
Abstract
The preliminary analyses on a multiscale model of intestinal crypt dynamics are here presented. The model combines a morphological model, based on the Cellular Potts Model (CPM), and a gene regulatory network model, based on Noisy Random Boolean Networks (NRBNs). Simulations suggest that the stochastic differentiation process is itself sufficient to ensure the general homeostasis in the asymptotic states, as proven by several measures.
Keywords
Cite
@article{arxiv.1309.7693,
title = {Analysis of the spatial and dynamical properties of a multiscale model of intestinal crypts},
author = {Giulio Caravagna and Alex Graudenzi and Marco Antoniotti and Giovanni de Matteis},
journal= {arXiv preprint arXiv:1309.7693},
year = {2013}
}
Comments
In Proceedings Wivace 2013, arXiv:1309.7122