AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Léna Carmès; Guillaume Bort; François Lux; Léa Seban; Paul Rocchi; Zeinaf Muradova; Agnès Hagège; Laurence Heinrich-Balard; Frédéric Delolme; Virginie Gueguen-Chaignon; Charles Truillet; Stephanie Crowley; Elisa Bello; Tristan Doussineau; Michael Dougan; Olivier Tillement; Jonathan Schoenfeld; Needa Brown; Ross Berbeco

doi:10.1039/D3NR04777F

AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Biological Physics 2024-01-05 v1

Authors: Léna Carmès , Guillaume Bort , François Lux , Léa Seban , Paul Rocchi , Zeinaf Muradova , Agnès Hagège , Laurence Heinrich-Balard , Frédéric Delolme , Virginie Gueguen-Chaignon , Charles Truillet , Stephanie Crowley , Elisa Bello , Tristan Doussineau , Michael Dougan , Olivier Tillement , Jonathan Schoenfeld , Needa Brown , Ross Berbeco

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Abstract

Comparison of click chemistry and sortagging grafting strategies for functionalizing AGuIX nanoparticles with nanobodies to develop a tri-functional technology combining MRI imaging, radiotherapy, and immunotherapy by inhibiting immune checkpoints.

Keywords

AGuIX nanoparticles nanobody bioconjugates immune checkpoint receptors click chemistry sortagging MRI imaging radiotherapy immunotherapy

Cite

@article{arxiv.2401.02149,
  title  = {AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors},
  author = {Léna Carmès and Guillaume Bort and François Lux and Léa Seban and Paul Rocchi and Zeinaf Muradova and Agnès Hagège and Laurence Heinrich-Balard and Frédéric Delolme and Virginie Gueguen-Chaignon and Charles Truillet and Stephanie Crowley and Elisa Bello and Tristan Doussineau and Michael Dougan and Olivier Tillement and Jonathan Schoenfeld and Needa Brown and Ross Berbeco},
  journal= {arXiv preprint arXiv:2401.02149},
  year   = {2024}
}

Comments

Nanoscale, 2024

AGuIX nanoparticle-nanobody bioconjugates to target immune checkpoint receptors

Abstract

Keywords

Cite

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