AgentGC: Evolutionary Learning-based Lossless Compression for Genomics Data with LLM-driven Multiple Agent
Abstract
Lossless compression has made significant advancements in Genomics Data (GD) storage, sharing and management. Current learning-based methods are non-evolvable with problems of low-level compression modeling, limited adaptability, and user-unfriendly interface. To this end, we propose AgentGC, the first evolutionary Agent-based GD Compressor, consisting of 3 layers with multi-agent named Leader and Worker. Specifically, the 1) User layer provides a user-friendly interface via Leader combined with LLM; 2) Cognitive layer, driven by the Leader, integrates LLM to consider joint optimization of algorithm-dataset-system, addressing the issues of low-level modeling and limited adaptability; and 3) Compression layer, headed by Worker, performs compression & decompression via a automated multi-knowledge learning-based compression framework. On top of AgentGC, we design 3 modes to support diverse scenarios: CP for compression-ratio priority, TP for throughput priority, and BM for balanced mode. Compared with 14 baselines on 9 datasets, the average compression ratios gains are 16.66%, 16.11%, and 16.33%, the throughput gains are 4.73x, 9.23x, and 9.15x, respectively.
Keywords
Cite
@article{arxiv.2601.13559,
title = {AgentGC: Evolutionary Learning-based Lossless Compression for Genomics Data with LLM-driven Multiple Agent},
author = {Sun Hui and Ding Yanfeng and Huidong Ma and Chang Xu and Keyan Jin and Lizheng Zu and Cheng Zhong and xiaoguang Liu and Gang Wang and Wentong Cai},
journal= {arXiv preprint arXiv:2601.13559},
year = {2026}
}