A Skew Normal Model of the Dose-Effect Relation in Pharmacology

Francis Lavergne; Nicolas Marie

A Skew Normal Model of the Dose-Effect Relation in Pharmacology

Methodology 2015-04-17 v1

Authors: Francis Lavergne , Nicolas Marie

Abstract

This paper deals with a skew-normal model of the relation between a dose $d > 0$ and a quantitative measure $E(d)$ of an effect of the administered drug. Precisely, $E(d)$ is a measure of the therapeutic response or a measure of a side-effect. Some existing and additional properties of the logistic functions are proved, and a skew-normal model of the escape time of rats under an experimental antidepressant medication is provided.

Keywords

skew-normal model dose-effect relation pharmacology logistic functions escape time

Cite

@article{arxiv.1504.04259,
  title  = {A Skew Normal Model of the Dose-Effect Relation in Pharmacology},
  author = {Francis Lavergne and Nicolas Marie},
  journal= {arXiv preprint arXiv:1504.04259},
  year   = {2015}
}

Comments

10 pages, 3 figures

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