A Pixel-by-Pixel Path to Population III Discovery with JWST

The identification of the first generation of metal-free stars, known as Population III (Pop~III), remains a primary goal of modern observational astronomy. While JWST has discovered an abundance of UV-bright galaxies at $z > 10$, distinguishing primordial stellar populations from early metal-enriched systems is a significant challenge. We present an end-to-end framework that combines physically motivated forward modelling from Yggdrasil primordial models with simulation-based inference (SBI) to test Pop~III detectability in JWST-like observations, from isolated sources to realistic overlap with enriched (Pop~II) hosts. Our analysis spans several Pop~III initial mass function (IMF) assumptions, nebular configurations, and Lyman-$\alpha$ transmission scenarios, while mocking the noise properties and filter coverage of the JWST Advanced Deep Extragalactic Survey (JADES). We find that unresolved or integrated analyses are strongly limited by host-galaxy contamination, whereas spatially resolved, pixel-based model comparison substantially improves recoverability. In our resolved experiments, detectability is highest for young and massive Pop~III clumps in nearly-quenched hosts at larger projected separations from their centres, reaching $\sim 90\%$ recovery in favourable configurations, while older and centrally embedded clumps are rarely recovered. Applying the framework to a literature candidate yields spatially differentiated behaviour: a compact blue companion is preferentially described by Pop~III-like models, while the host is better explained by fiducial Pop~I/II models. Our pipeline provides practical criteria for future searches and motivates imaging-first, spectroscopy-assisted strategies for identifying primordial stellar populations in JWST data.