We model a general, hierarchically organized tissue by a multi compartment approach, allowing any number of mutations within a cell. We derive closed solutions for the deterministic clonal dynamics and the reproductive capacity of single clones. Our results hold for the average dynamics in a hierarchical tissue characterized by an arbitrary combination of proliferation parameters.
@article{arxiv.1305.3043,
title = {A deterministic model for the occurrence and dynamics of multiple mutations in hierarchically organized tissues},
author = {B. Werner and D. Dingli and A. Traulsen},
journal= {arXiv preprint arXiv:1305.3043},
year = {2013}
}