A complex network analysis of hypertension-related genes
Molecular Networks
2016-01-28 v1 Biological Physics
Medical Physics
Abstract
In this paper, a network of hypertension-related genes is constructed by analyzing the correlations of gene expression data among the Dahl salt-sensitive rat and two consomic rat strains. The numerical calculations show that this sparse and assortative network has small-world and scale-free properties. Further, 16 key hub genes (Col4a1, Lcn2, Cdk4, etc.) are determined by introducing an integrated centrality and have been confirmed by biological/medical research to play important roles in hypertension.
Keywords
Cite
@article{arxiv.1601.07192,
title = {A complex network analysis of hypertension-related genes},
author = {Huan Wang and Chuan-Yun Xu and Jing-Bo Hu and Ke-Fei Cao},
journal= {arXiv preprint arXiv:1601.07192},
year = {2016}
}
Comments
13 pages, 6 figures, 3 tables; a revised version of an article published in Physica A: Statistical Mechanics and its Applications