Motivated by Berg's notion of quasi-disjointness for ergodic systems, we introduce and investigate the concept of quasi-disjointness for minimal systems. Several equivalent characterizations are provided. We prove that quasi-disjointness is preserved under taking factors, proximal extensions, and group extensions. As a consequence, we establish that every minimal {\bf PI} system is quasi-disjoint from all minimal systems. In addition, some variant of quasi-disjointness, namely strong quasi-disjointness is also introduced and examined. Particularly, we prove that each {\bf AI} system is strongly quasi-disjoint from all minimal systems.